منابع و داده های رتبه بندی دانشگاههای کشور
آخرین مقالات ISI ایرانیان که در ژورنالها و مجامع بین المللی منتشر شده
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Oral Health Determinants among Opium Users in Kerman, Iran.نویسندگان مقاله Amir Hossein Nekouei, Sina Kakooei, Hamid Najafipour, Shahla Kakoei,لینک مقاله اصلی: http://dx.doi.org/10.22122/ahj.v13i3.307محل انتشار : Addiction & health
چکیده مقاله
Promoting oral health is a complicated issue among drug abusers and opium is the most frequent drug abused in Iran. This study aims to find the oral health determinants of opium users in Kerman, Iran.This cross-sectional study was a part of the second phase of Kerman coronary artery disease risk factors study (KERCADRS, 2014-2018). In this survey, the data of 1140 opium users were analyzed. The information about using a toothbrush, dental floss, number of dental visits at last year, age of first use of opium, duration, and opium consumption frequency was recorded. The total number of decayed, missing, and filled teeth (DMFT) index and Community Periodontal Index (CPI) was recorded by an oral examination. Poisson and logistic regressions analyses were used for assessing the relationship among variables.The mean age of participants was 52 ± 12 years. 74.4% were men and 24.6% were women. The average DMFT index was 15.7 ± 7.6 and the prevalence of a healthy CPI score was 18.5%. Educational level (P < 0.001), brushing (P < 0.001), flossing (P < 0.001), dental visit (P < 0.001), first age of using opium (P < 0.001), frequency of consumption (P < 0.001), and age (P < 0.001) were associated with DMFT index. Only using floss (P < 0.001), dental visit [odds ratio (OR) = 1.80, P = 0.030], frequency of consumption (OR = 2.92, P < 0.001), and age (P = 0.001) were associated with CPI score.The frequency of opium consumption has the same effect on caries incidence as oral hygiene habits. Moreover, using dental floss has a more significant effect on the periodontal health of participants.
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Information Needs of Addicted Individuals: A Qualitative Case Study.نویسندگان مقاله Maryam Eslami-Jahromi, Sareh Keshvardoost, Roghayeh Ershad-Sarabi, Kambiz Bahaadinbeigy,لینک مقاله اصلی: http://dx.doi.org/10.22122/ahj.v13i3.312محل انتشار : Addiction & health
چکیده مقاله
The purpose of this study was to investigate the information needs of addicts from the perspective of addicts. By identifying the experiences of the individuals involved in addiction and assessing the information they need, targeted educational interventions can be provided to meet their needs.Semi-structured interviews were conducted with 13 addicts in two addiction outpatient clinics. Data were analyzed using the qualitative content analysis approach proposed by Graneheim and Lundman.The information needs of the interviewees included recognizing types of addictive substances and the degree of dependence on them, awareness of the physical and psychological symptoms of addiction to various addictive substances, awareness of various pharmacological and non-pharmacological treatments, physical and psychological symptoms of quitting addiction, awareness of the length of treatment, knowledge about the dose and degree of dependence on drugs, recognizing the causes of failure in quitting addiction, awareness of governmental and non-governmental services, and awareness of the psychological measures and care services necessary after quitting addiction.The results of the study showed that the knowledge and awareness of addicted individuals in various fields of addiction is low and it is necessary to provide education based on the information needs of these individuals. This requires the cooperation and efforts of policy makers, the Ministry of Education, welfare managers, and specialists in camps and addiction treatment centers. Specialists in addiction treatment clinics can use the information needs of addicts determined in this study to enrich the education of addicts.
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Comparing Two Orthoses for Managing Medial Knee Osteoarthritis: Lateral Wedge with Subtalar Strap While Barefoot Versus Lateral Wedged Insole Fitted Within Sandal.نویسندگان مقاله Maryam Falahatgar, Maryam Jalali, Taher Babaee, Zahra Safaeepour, Ali Torkaman, Mina Baniasad,لینک مقاله اصلی: http://dx.doi.org/10.1016/j.medengphy.2020.12.002محل انتشار : Indian journal of orthopaedics
چکیده مقاله
Using foot orthoses for managing medial knee osteoarthritis (MKOA) is common, although its effectiveness is in debate. Most orthoses are placed inside the shoe as a lateral wedged insole. Thus, most studies in this area have focused on the effect of insoles used with shoes. This study compared the effects of a lateral wedge with subtalar strap (combined insole) used while barefoot and lateral wedged insole fitted within sandal on pain, function and external knee adduction moment (EKAM) in patients with MKOA to consider which orthotic treatment is better.In this quasi-experimental pretest-posttest study, 29 participants with medial knee osteoarthritis were divided into two groups: (1) combined insole (The pain immediately decreased after walking with both orthoses (Both types of orthoses have similar effect and lead to better performance and less pain after 1 month.
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Computed tomography scan in COVID-19: a systematic review and meta-analysis.نویسندگان مقاله Pouya Mahdavi Sharif, Mehran Nematizadeh, Mahdia Saghazadeh, Amene Saghazadeh, Nima Rezaei,لینک مقاله اصلی: http://dx.doi.org/10.1101/2020.03.04.20026005محل انتشار : Polish journal of radiology
چکیده مقاله
Computed tomography (CT) scan is a commonly used tool for the diagnosis of the novel coronavirus disease 2019 (COVID-19), similarly to reverse transcription-polymerase chain reaction (RT-PCR). Because of the limitations of RT-PCR, there is growing interest in the usability of the CT scan. The present systematic review and meta-analysis aims to summarize the available data on the CT scan features of COVID-19.We conducted a systematic search in electronic databases to find eligible studies published between 1 December 2019 and 4 April 2020, which investigated the computed tomographic features of patients with COVID-19. All preprint and peer-reviewed articles were included. No language limitation was applied. For proportional data, pooled prevalence was calculated using a Freeman-Tukey double arcsine transformation, with a 95% confidence interval (CI).Eighty-six studies were eligible to be included in the meta-analysis. For 7956 patients, the most common CT findings were bilateral pattern of involvement (78%; 95% CI: 0.73-0.82; Our study results show that COVID-19 shares some features with other viral types of pneumonia, despite some differences. They commonly present as GGO along with vascular thickening, air bronchogram and consolidations. Normal CT images, lymphadenopathies, and pleural effusions are not common. Consolidations and pleural effusions correlate with more severe disease. CT features are different between COVID-19 and non-COVID-19 pneumonia. Also, they differ by age, disease severity, and outcomes within COVID-19 patients.
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The Burden of Likely Rubella Infection among Healthy Pregnant Women in Abakaliki, Ebonyi State, Nigeria.نویسندگان مقاله Uchechukwu Onyeukwu Ekuma, Ogbonnaya Ogbu, Angus Nnamdi Oli, Martin-Luther Oseni Okolo, Peter Anyigor Edeh, Hussein O M Al-Dahmoshi, Sousan Akrami, Morteza Saki,لینک مقاله اصلی: http://dx.doi.org/10.1016/j.ijid.2018.07.024محل انتشار : Interdisciplinary perspectives on infectious diseases
چکیده مقاله
The first 140 days of pregnancy are critical as regards rubella virus infection because of the likelihood of a poor pregnancy outcome. This study was undertaken to investigate the likelihood of exposure to poor pregnancy outcomes due to seroprevalence of rubella among selected pregnant women attending Mile Four Hospital, Abakaliki, Ebonyi State, Nigeria. The seroprevalence of rubella immunoglobulin M (IgM) antibodies was investigated among pregnant women. A total of 187 sera samples collected from the women were screened for rubella virus IgM antibody using the enzyme-linked immunosorbent assay (ELISA). The results obtained were analyzed using SPSS. The chi square test was performed at a
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Case Report: Mutation in AIMP2/P38, the Scaffold for the Multi-Trna Synthetase Complex, and Association With Progressive Neurodevelopmental Disorders.نویسندگان مقاله Mahta Mazaheri, Mahdie Yavari, Hadi Zare Marzouni, Angela Stufano, Piero Lovreglio, Simona S'Amore, Hamid Reza Jahantigh,لینک مقاله اصلی: http://dx.doi.org/10.1212/con.0000000000000338محل انتشار : Frontiers in genetics
چکیده مقاله
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LncRNA-miRNA-mRNA Networks of Gastrointestinal Cancers Representing Common and Specific LncRNAs and mRNAs.نویسندگان مقاله Hassan Dastsooz, Ahad Alizadeh, Parham Habibzadeh, Ali Nariman, Asieh Hosseini, Yaser Mansoori, Hamed Haghi-Aminjan,لینک مقاله اصلی: http://dx.doi.org/10.7150/ijms.53531محل انتشار : Frontiers in genetics
چکیده مقاله
Gastrointestinal (GI) cancers are responsible for approximately half of cancer-related deaths, highlighting the need for the identification of distinct and common features in their clinicopathological characteristics. Long ncRNA (lncRNAs), which are involved in competitive endogenous RNA (ceRNA) networks with critical roles in biological processes, constitute a substantial number of non-coding RNAs. Therefore, our study aimed to investigate the similarities and differences in the ceRNA networks of The Cancer Genome Atlas (TCGA)-GI cancers. We performed a comprehensive bioinformatics analysis of ceRNA networks for TCGA-GI cancers in terms of the deferential mRNA, lncRNA, and miRNA expression levels, ceRNA networks, overall survival analysis, correlation analysis, pathological cancer stages, and gene set enrichment analysis. Our study revealed several common and distinct mRNAs and lncRNAs with prognostic values in these networks. It was specifically noteworthy that
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Perceived Functions of Playfulness in Adult English as a Foreign Language Learners: An Exploratory Study.نویسندگان مقاله Elyas Barabadi, Majid Elahi Shirvan, Mojdeh Shahnama, René T Proyer,لینک مقاله اصلی: http://dx.doi.org/10.4236/health.2013.512294محل انتشار : Frontiers in psychology
چکیده مقاله
Influenced by the flowering of positive psychology in the field of foreign language acquisition research in recent years, the present study aimed to explore the perceived functions of playfulness, as a personality construct, among English as a foreign language (EFL) learners. To this aim, an initial sample of 38 EFL learners were selected randomly from the private language institutes of Mashhad, the second largest city in Iran. They were interviewed about any perceived functions of playfulness in the EFL learning context. A qualitative content analysis of the collected data led to the extraction of four categories: Fun and laughter, creativity, mastery orientation, and cultivating relationships. A further in-depth analysis of the categories and comparison with the functions of adult playfulness in psychology (primarily Proyer's 2014 and 2017 works of research) revealed that these four categories can be subsumed under two of the four structural components of adult playfulness; namely, other-directed playfulness and intellectual playfulness. The ability of EFL learners to turn language learning situations, tasks, and environment into enjoyable ones via their playfulness can have implications for the quality of their interpersonal interactions in class and eventually their language proficiency. The findings of this study can pave the way for the translation of the adult playfulness construct from developmental and personality psychology and family relations into the second language acquisition (SLA) domain and its conceptualization in future research in this domain.
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Examining exclusive breastfeeding in Iranian mothers using the five-factor model of personality traits.نویسندگان مقاله Fatemeh Padashian, Parvin Yadollahi, Marziyeh Doostfatemeh, Zeinab Moshfeghy,لینک مقاله اصلی: http://dx.doi.org/10.1016/j.jtumed.2021.08.002محل انتشار : Journal of Taibah University Medical Sciences
چکیده مقاله
The initiation of exclusive breastfeeding and its continuation plays a vital role in maternal and child health. This study investigates the prediction of exclusive breastfeeding in Iranian mothers using the five-factor model.A descriptive correlational study was conducted using cluster random sampling. and 120 mothers with children aged 6 to 12 months, referred to health centres of Shiraz University of Medical Sciences in Valfagr and Enghelab in Iran, participated in this cross-sectional study. The participants were requested to fill 3 questionnaire containing demographic questionnaire, the exclusive breastfeeding scale, and the Big Five factors (BFF) questionnaire of personality traits. The data were collected between May and December 2019 and analysed using Pearson's correlation coefficient and multiple regression.The results showed that the agreeableness trait had the highest score (mean score = 16.13, SD = 2.10) and the neuroticism trait had the lowest score (mean score = 12.13, SD = 2.68). The main results indicated a significant relationship between the extraversion trait and exclusive breastfeeding (r = 0.36, Personality traits may potentially affect exclusive breastfeeding and could be a useful tool in reducing impediments to exclusive breastfeeding and in identifying mothers who need more mental support.إن بدء الرضاعة الطبيعية الحصرية واستمرارها يلعب دورا حيويا في صحة الأم والطفل. تبحث هذه الدراسة في التنبؤ بالرضاعة الطبيعية الحصرية للأمهات الإيرانيات باستخدام نموذج العوامل الخمسة للسمات الشخصية.شارك في هذه الدراسة المقطعية ما مجموعه ١٢٠ أمّا، لديهن أطفال تتراوح أعمارهم بين ٦ إلى ١٢ شهرا، تمت إحالتهم إلى مراكز الصحة في شيراز في إيران. طُلب من المشاركات ملء استبانة ديموغرافية، ومقياس الرضاعة الطبيعية الحصري، ومقياس العوامل الخمسة الكبرى لسمات الشخصية. كما تم تحليل البيانات باستخدام معامل ارتباط بيرسون والانحدار المتعدد.أظهرت النتائج أن صفة التوافق حصلت على أعلى درجة (متوسط الدرجات = ١٦.١٣، والانحراف المعياري = ٢.١٠) وسجلت صفة العصابية أقل درجة (متوسط الدرجة = ١٢.١٣، والانحراف المعياري = ٢.٦٨). أشارت النتائج الرئيسة إلى وجود علاقة معنوية بين سمة الانبساط والرضاعة الطبيعية الحصرية (معامل الارتباط =٠.٣٦) في تحليل الانحدار، وكانت النتائج تدل على التنبؤ الإيجابي بالرضاعة الطبيعية الحصرية لكل من سمة الانبساط (بيتا=٠.٤٣) وسمة الضمير (بيتا=٠.١٨).قد تؤثر سمات الشخصية على الرضاعة الطبيعية الحصرية، ويمكن أن تكون أداة مفيدة في تقليل العوائق التي تحول دون الرضاعة الطبيعية الحصرية، وفي تحديد الأمهات اللائي يحتجن إلى مزيد من الدعم النفسي.
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Acceleration of antibacterial activity of curcumin loaded biopolymers against methicillin-resistantنویسندگان مقاله Hamoun Anbari, Amir Maghsoudi, Mohammadreza Hosseinpour, Fatemeh Yazdian,لینک مقاله اصلی: http://dx.doi.org/10.1016/j.msec.2017.03.032محل انتشار : Engineering in Life Sciences
چکیده مقاله
Curcumin is a polyphenolic molecule with antibacterial, antioxidant, anti-inflammatory, and antimicrobial properties. This study aimed to prepare nanocurcumin by encapsulating in biopolymers to improve its stability, bioavailability, water-solubility, antibacterial efficiency against methicillin-resistant
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Evaluation of S100A12 and Apo-A1 plasma level potency in untreated new relapsing-remitting multiple sclerosis patients and their family members.نویسندگان مقاله Mahsa Samangooei, Mojtaba Farjam, Masoud Etemadifar, Atefeh Taheri, Mohammad Hassan Meshkibaf, Bahram Movahedi, Zahra Niknam, Saam Noroozi,لینک مقاله اصلی: http://dx.doi.org/10.1001/jama.296.23.2832محل انتشار : Scientific reports
چکیده مقاله
Multiple sclerosis is an inflammatory disease of the spinal cord and brain. Receptor for advanced glycation end products and Apolipoprotein A1 (Apo-AI) have been recommended to have a pathogenic role in the neuroinflammatory disorder as multiple sclerosis. The purpose of this research was to measure the plasma levels of S100A12 and Apo-A1 in the first-degree family of relapsing-remitting multiple sclerosis (RRMS) patients. Plasma levels of S100A12 & Apo-A1 were evaluated via enzyme-linked immunosorbent assay in the thirty-five new cases of untreated patients with deterministic RRMS according to the McDonald criteria, twenty-four healthy controls, and twenty-six first-degree members of untreated RRMS patients (called them as high-risk group). The main findings of this study were as follows: the plasma level of S100A12 was significantly lower in the new cases of untreated RRMS (P ≤ 0.05; 0.045) and high-risk (P ≤ 0.05; 0.001) groups. Although the plasma protein level of Apo-A1 was reduced significantly in the high-risk group (P < 0.05, P = 0.003) as compared to the healthy control group, there was no significant difference in the untreated RRMS patients (P = 0.379). The plasma level of vitamin D3 in both RRMS patients and high-risk groups displayed significance reduction, although, there was no significant association between vitamin D and S100A12 & Apo-A1 levels. Given the role of S100A12 and Apo-A1 in the inflammatory process performed in the first-degree family members of the RRMS patients, which revealed a significant decrease in this group, we concluded that they can be considered as one of the contributing factors in the pathogenesis of MS, though more research is needed before assuming them as predictive biomarkers.
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Antiproliferative effects of AAV-delivered CRISPR/Cas9-based degradation of the HPV18-E6 gene in HeLa cells.نویسندگان مقاله Zahra Noroozi, Mehdi Shamsara, Elahe Valipour, Sahar Esfandyari, Alireza Ehghaghi, Amir Monfaredan, Zahra Azizi, Elahe Motevaseli, Mohammad Hossein Modarressi,لینک مقاله اصلی: http://dx.doi.org/10.1089/hgtb.2011.034محل انتشار : Scientific reports
چکیده مقاله
Human papillomavirus infections are associated with most cervical cancers, which are the fourth most common cancer in women. HPV-E6 protein binds to protein p53 and inhibits its function, leading to the switching of normal cells toward cancer cells. Here, we disrupted the HPV-E6 gene and investigated its effects on the proliferation and apoptosis of HeLa cells. The HPV18-E6 gene was targeted with two designed sgRNAs cloned into an AAV-CRISPR-based plasmid. The AAV-E6-CRISPR/Cas9 virions were prepared and titrated in HEK293t cells. The cleavage created in the HPV-E6 gene was detected using the T7E1 assay. Cell cycle profiling, MTT assay, and annexin V/PI staining were performed. Also, the p53 protein level was measured by Western blotting. Our data showed that disruption of the HPV-E6 gene led to increased cell apoptosis and decreased cell proliferation. A significant accumulation of infected cells in sub-G1 phase was observed in the cell profiling assay. Also, HPV-E6 gene disruption resulted in a significant increase in the level of P53 protein. Our findings indicated that AAV-mediated delivery of CRISPR/Cas9 can effectively target the HPV-E6 gene in HeLa cells, and its antiproliferative effects may provide therapeutic benefits of local administration of this gene-editing system for HPV-related cervical cancers.
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Screening of rice drought-tolerant lines by introducing a new composite selection index and competitive with multivariate methods.نویسندگان مقاله Atefeh Sabouri, Ahmad Reza Dadras, Matin Azari, Abbas Saberi Kouchesfahani, Mehraneh Taslimi, Reza Jalalifar,لینک مقاله اصلی: http://dx.doi.org/10.1002/aps3.11278محل انتشار : Scientific reports
چکیده مقاله
Selection and breeding for drought tolerance in rice have always been one of the leading objectives for rice breeders in water-deficient farming areas. In the present study, we applied the potential of recombinant inbred lines (RILs) population, which were derived from cross Shahpasand (Iranian landrace) and IR28, for the development of drought-tolerant rice lines. One hundred fifty-two lines along with five check varieties were investigated from 2017 to 2019 under non-stress and drought stress conditions. The yield reduction caused by drought based on overall mean during 2017, 2018, and 2019 were estimated to be 89.40, 57.95, and 35.31%, respectively. Using different statistical methods, certain lines, including L33, L90, and L109, which are considered as the best lines in most environments, were found to be promising for being utilized to increase rice drought tolerance. The averages of grain yield of the above-mentioned lines were respectively 6.45, 5.80, and 5.70 t ha
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Patents and intellectual property assets as non-fungible tokens; key technologies and challenges.نویسندگان مقاله Seyed Mojtaba Hosseini Bamakan, Nasim Nezhadsistani, Omid Bodaghi, Qiang Qu,لینک مقاله اصلی: http://dx.doi.org/10.1016/j.tele.2018.11.006محل انتشار : Scientific reports
چکیده مقاله
With the explosive development of decentralized finance, we witness a phenomenal growth in tokenization of all kinds of assets, including equity, funds, debt, and real estate. By taking advantage of blockchain technology, digital assets are broadly grouped into fungible and non-fungible tokens (NFT). Here non-fungible tokens refer to those with unique and non-substitutable properties. NFT has widely attracted attention, and its protocols, standards, and applications are developing exponentially. It has been successfully applied to digital fantasy artwork, games, collectibles, etc. However, there is a lack of research in utilizing NFT in issues such as Intellectual Property. Applying for a patent and trademark is not only a time-consuming and lengthy process but also costly. NFT has considerable potential in the intellectual property domain. It can promote transparency and liquidity and open the market to innovators who aim to commercialize their inventions efficiently. The main objective of this paper is to examine the requirements of presenting intellectual property assets, specifically patents, as NFTs. Hence, we offer a layered conceptual NFT-based patent framework. Furthermore, a series of open challenges about NFT-based patents and the possible future directions are highlighted. The proposed framework provides fundamental elements and guidance for businesses in taking advantage of NFTs in real-world problems such as grant patents, funding, biotechnology, and so forth.
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Phenylalanine gold nanoclusters as sensing platform for π-π interfering molecules: a case study of iodide.نویسندگان مقاله Amir Amiri-Sadeghan, Ali Dinari, Soheila Mohammadi, Tayebeh Zohrabi, Reza Khodarahmi, Saman Hosseinkhani, Jungwon Yoon,لینک مقاله اصلی: http://dx.doi.org/10.1038/s41598-022-05155-5محل انتشار : Scientific reports
چکیده مقاله
The photo-physical properties of metal nano clusters are sensitive to their surrounding medium. Fluorescence enhancement, quenching, and changes in the emitted photon properties are usual events in the sensing applications using these nano materials. Combining this sensitivity with unique properties of self-assembled structures opens new opportunities for sensing applications. Here, we synthesized gold nanoclusters by utilizing phenylalanine amino acid as both capping and reducing molecule. Phenylalanine is able to self-assemble to rod-shaped nano structure in which the π-π interaction between the aromatic rings is a major stabilizing force. Any substance as iodide anion or molecule that is able to weaken this interaction influence the fluorescence of metal nano-clusters. Since the building blocks of the self-assembled structure are made through the reaction of gold ions and phenylalanine, the oxidized products and their effect of sensing features are explored.
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The role of small ruminants in the epidemiology of leptospirosis.نویسندگان مقاله Mohammad Rahim Haji Hajikolaei, Sareh Rezaei, Ali Reza Ghadrdan Mashhadi, Masoud Ghorbanpoor,لینک مقاله اصلی: http://dx.doi.org/10.1016/j.diagmicrobio.2008.10.017محل انتشار : Scientific reports
چکیده مقاله
Leptospirosis is a common global zoonotic disease of man and all farm animals. Although most leptospiral infections in sheep and goats are asymptomatic, they may play a role in the epidemiology of the disease by the spread of Leptospira through the urine. This study was carried out to evaluate the role of sheep and goats in the epidemiology of leptospirosis. Blood and urine samples were taken from 210 goats and 246 sheep. To detect antibodies, sera samples were tested with 8 live serovars of L. interrogans (Hardjo, Pomona, Grippotyphosa, Canicola, Ballum, Icterhemorrhagiae, Tarasovi, and Australis) by MAT. Then, urine samples were tested by Nested PCR targeting 16S rRNA gene for detection of pathogenic Leptospira. Results of MAT showed that 10.95% of goats and 8.53% of sheep had antibodies against at least one examined serovars. In both species, the highest reacting was L. i. Pomona with a rate of 68.18% and 56% in sheep and goats, respectively. Moreover, in PCR, 2 (0.95%) urine samples of goat and 12 (4.87%) urine samples of sheep were positive. All of the MAT positive studied animals were PCR negative and, statistical analysis showed that there was no relationship and agreement between the results of PCR and MAT in sheep (kappa = - 0.07, p > 0.05) and goats (kappa = - 0.02, p > 0.05). Finally, it is concluded that sheep and goats can excrete L. interrogans in the urine and thus transmit them to other animals and humans.
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Genotypes and phenotypes characterization of 17 Iranian patients with inherited factor X deficiency: identification of a novel mutation: Leu487Phe.نویسندگان مقاله Aysan Fallah, Mahmood Shams, Elnaz Agi, Mohammad Jazebi, Mohammad R Baghaipoor, Tohid Naderi, Mohammad R Rezvany,لینک مقاله اصلی: http://dx.doi.org/10.1097/MBC.0000000000001101محل انتشار : Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
چکیده مقاله
Factor X deficiency is a rare bleeding disorder that affects almost 1 : 1000 000 people worldwide. It derives from multiple mutational changes in the factor X gene (F10). The main objective of the present study was to determine a consistent correlation between the clinical presentations and causative genotype. The phenotype and genotype of 17 Iranian patients with reduced factor X activity (FX:C) from 14 unrelated families were analyzed to screen factor X gene expression for any possible mutations and function alteration. Analysis of the sequencing results led to the identification of eight different mutations besides a single nucleotide variation. One of the mutations was novel (Leu487Phe) as studied by means of online analysis programs and molecular modeling. Eight patients were homozygote; three were heterozygote, while six out of 17 patients were symptomatic cases without any mutations. The Arg40Thr missense mutation was detected in three patients including two siblings and was associated with severe bleeding symptoms. Also, two patients were identified with Gly262Asp missense mutation which commonly presented with bleeding disorder. Each of the other patients was associated with a unique missense mutation including one novel mutation in which the tentative relation of the mutation to bleeding symptoms is reported. Mutations leading to a FX:C of less than 1% are associated with severe bleeding symptoms confirming the strong correlation between clinical severity and FX:C. The novel Leu487Phe mutation with FX:C of 13% may have possible negative effects on factor X protein function resulting in minor clinical manifestation.
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Microstructural and Analytical Study of Uncommon Corrosion Features on Archaeological Cu-As Alloys from Tappeh Graziani in Southeastern Iran.نویسندگان مقاله Mohammad Mortazavi, Hosseinali Kavosh, Sogand Naghavi, Reza Khanjari,لینک مقاله اصلی: http://dx.doi.org/10.1017/S1431927622000137محل انتشار : Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada
چکیده مقاله
The morphology and composition of the corrosion products of archaeological arsenical copper alloys buried in a specific environment for a long time were investigated using optical microscopy (OM), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS), micro X-ray fluorescence (μ-XRF), and X-ray diffraction (XRD). The analyses demonstrated that the alloy composition of the artifacts was copper-arsenic (Cu-AS) with significant amounts of lead in some samples. Cuprite, malachite, and copper (II) hydroxychlorides were observed on a completely mineralized matrix. The surface of the objects was covered by two main corrosion layers formed on the internal cuprous oxide. However, several successive layers of corrosion products were recognized on the artifacts in some cases. Furthermore, phosphatic corrosion products including, mimetite [Pb5(AsO4)3Cl], and pyromorphite [Pb5(PO4)3Cl] were identified. Conichalcite [CaCu(AsO4)](OH), which grew in the form of Liesegang rings, was also identified as a corrosion product of one of the objects. As and Pb exhibited some enrichment in the corrosion crusts of the artifacts. Environmental changes in burial conditions, particularly due to seasonal streams and consequent changes in soil corrosivity, vicinity of objects to bone material, along with the migration of alloy elements, especially lead and arsenic, can explain the morphological features of these archaeological objects.
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Spontaneous tumor lysis syndrome in adrenal adenocarcinoma: a case report and review of the literature.نویسندگان مقاله Mahan Shafie, Alireza Teymouri, Samaneh Parsa, Ali Sadeghian, Narjes Zarei Jalalabadi,لینک مقاله اصلی: http://dx.doi.org/10.1016/j.clon.2006.09.005محل انتشار : Journal of medical case reports
چکیده مقاله
Tumor lysis syndrome is an oncologic emergency that classically occurs following cancer therapy, although spontaneous tumor lysis syndrome can also occur in malignancies, albeit rarely. Spontaneous tumor lysis syndrome has previously been reported in some hematologic malignancies, but it rarely happens in solid tumors and seems to be associated with a higher mortality rate. This is the first case of adrenal adenocarcinoma that developed spontaneous tumor lysis syndrome.We present a rare case of spontaneous tumor lysis syndrome occurring in a patient previously diagnosed with adrenal adenocarcinoma. The patient was a 64-year-old Persian man with abdominal pain, hypersomnia, and fatigue who was previously diagnosed with right adrenocortical carcinoma and had undergone right adrenalectomy with regional lymph nodes resection 5 months previously. On physical examination, the patient had abdominal distension and mild tenderness at the right upper quadrant. Pitting edema was detected bilaterally in the lower extremities. Initial imaging revealed multiple and large lesions suggestive of liver metastases. The laboratory data showed hyperkalemia, hyperuricemia, hyperphosphatemia, and elevated serum creatinine level indicative of spontaneous tumor lysis syndrome in the patient. Despite immediate and intensive care with antibiotics, hydration, treatment with a hypouricemic agent, and renal replacement therapy, the patient ultimately died from multiorgan failure.Tumor lysis syndrome in solid tumors has high mortality. Patients susceptible to spontaneous tumor lysis syndrome must receive aggressive treatment immediately, which is crucial for preventing morbidity and mortality. Spontaneous tumor lysis syndrome may be underdiagnosed, and a high degree of clinical suspicion is needed to make the diagnosis and proceed with required interventions. Therefore, clinicians should be aware of this rare phenomenon.